New Diabetes Cure in Islet Pancreatic Transplantation
Remember 13 years ago when University of Alberta developed a method to transplant the islet by injecting cells from a cadaverous pancreas into the recipients’ liver? At first there was a 10% chance the patients would be insulin free for five years. That rate of success has now gone up to 50%. They are now moving forward with three new trials. So far they have enough donors and a short waiting list for patients.
What's with the new diabetes cure? Pancreatic islet transplantation is becoming an alternative to insulin treatment, that's what. The beneficiary for this is the patient suffering from type 1 brittle diabetes. But there is still a main problem to overcome.
So Florencia M. Barbe-Tuana et al studied this and found that the major problem in the procedure is the inflammation in the area of the implantation. They recently discovered that CD40 is expressed in pancreatic cells which is usually linked to inflammation.
They investigated the role of CD-40 further in both human and primate islets and found that inflammation is induced. This contributes to the loss of the islet graft early after the transplantation. During this process, the transplanted islets are vulnerable to rapid damage due to the inflammation.
It's a good thing they're studying this for this helps the new diabetes cure to come closer. You see, the data the researchers came out with showed that the interaction in the islet cells encourages the secretion of molecules during transplantation which could lead to the death of the cells and thus early graft loss.
It is true that advances have been made in the ways of isolating the islets and in the use of immunosuppressive routine. This success led to more clinical trials in order to establish islet transplantation as a treatment. It is studied as a therapeutic option for those who have type 1 diabetes.
This group is the first to report that the beta cells secrete what they call MIP-1B. They did not observe this before so this must have been due to the isolation stress. This is important knowledge to pile up to help with the quest for a new treatment option.
They also found that after the transplantation, the islets are liable to be affected not only by inflammation but also by hypoxia or to diminished supply of oxygen. They said the use of blockers right after the isolation could improve the islets' vulnerability. This could only lead to more successful clinical trials that will lead to the new diabetes cure.
What will be helpful at this point is to develop strategies to slow down or prevent the CD40 from extracting in the pancreatic cells. Considering this during the process of obtaining organs and the islet isolation methods will only lead to successful islet transplantation as a new diabetes cure.
Here is the latest news on pancreatic islet transplantation. There is proof that Tissera's pancreatic xenotransplantation has just achieved an important goal in its search for a new diabetes cure. After successful pancreatic transplantation in the past, they carried on to further investigate the value of this treatment approach.
At the Weizmann Institute of Science, the scientists treated human primates with streptozotocin in order to make them diabetic and dependent on the administration of insulin. After a few weeks, the research team transplanted a pig embryonic pancreatic tissue into these primates.
To follow up the case, the scientists reduced the amount of insulin they administered. By the fourth month after the transplantation, only 10% of insulin was needed to maintain near normal blood sugar levels. And by the fifth month, the diabetic primates reached complete independence.
They also dealt with the issue of graft rejection and were successful at reducing the immune suppression treatment to counteract the rejection of the graft to the level fit for humans and with less side effects.
Now that they are at 31 weeks after transplantation, the primate is alive and well so Tissera is moving forward to conduct more studies to make this new diabetes cure a reality for people with type 1 diabetes.
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A Video on Diabetes for You
You may want to watch this video about pancreatic islet. It's three minutes long. And there are explanations at the end. Just click that arrow that points to the right, and it will start playing.
The one who made this video said he dedicates this to the greatest pathologist of all time - Dr. Martin Swerdlow. There were a lot who watched this video and one of them asked if islets of langerhans is affected in all types of diabetes. WDC explained that in insulin depended case which is type 1, the cells that secrete insulin are destroyed .
In contrast, the cells in type 2 do not respond to insulin so at the start there is no damage in the islets but as the condition advances, the beta cells keep increasing the secretion of insulin until they get so worn out from overwork, the pancreas just give up.
Then there is a comment from Symptoms Free Diabetes and he said that GlyPerfect worked for him. I don't know what relevance this has for the video, because I watched it three times to see if it's good for my readers before uploading it to my website and I didn't hear anything about GlyPerfect.
I'll keep researching for GlyPerfect though because if it worked for him and rendered him free from symptoms of diabetes after twenty years of battling the disease, then I want that for my readers as well if my research will show that it is both safe and effective. He said his blood sugar stabilized and his A1c test showed his blood glucose level dropped to 6.2 from 8.2.
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