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Advancement Reported on Cholesterol and Fatty Acids Reduction

A way to reduce the bad cholesterol and fatty acids have been uncovered by researchers in Edmonton, Canada's University of Alberta. We know that this bad cholesterol and the fatty acids end up in the blood when the body metabolizes the food.

This is an important discovery in the sense that it could lead to new therapy to treat and stop the effects of heart disease and type 2 diabetes which is linked to obesity. We also know that lack of physical activity and too much sugar and fat intake lead to diabetes and heart disease.

The above led the University of Alberta's researchers to study the mechanism behind it. Dr. Richard Lehner and his team were successful in reducing the low density lipids (LDL) and triglycerides in the blood of hamsters and mice. How did they do this?

What they did was influence a particular enzyme to find out how exactly do eating too much fat and sugar and lack of physical activity lead to bad cholesterol. In so doing they found out how an enzyme lets the fatty acids in the liver and fat cells go to the blood and more importantly how to prevent this from happening.

This is an important finding because at the present what is employed to reduce the bad cholesterol are drugs called statins. But this does not treat obesity which is a risk factor in developing type 2 diabetes and heart disease. So the discovery on how to stop the enzyme from releasing the fatty acids into the blood could trigger effort at discovering what can stop this enzyme from doing this.

Dr. Lehner said there is a need for further testing. Also, it should be noted that whatever therapy they discover from this to treat obesity should not be regarded as a magical breakthrough. People should still make wise choices as to what they eat and to exercise in order to achieve optimum health.

Conference to Encourage Diabetics and Their Families

There will be a diabetes conference on February 2, 2008 from 8:30 to 5 p.m. Saturday. It is a one-day conference that will be held at the Indianapolis Convention Center. The conference is called "Taking Control of Your Diabetes" and it is designed to inform and support the diabetics and their families.

David Marrero, PhD, Paris Roach, M.D. and Melinda S. Kelly, R.N. who is a diabetes educator are the co-directors of this program. They are from the Division of Endocrinology and Metabolism of the School of Medicine at Indiana University.

Diabetes Prevention Program Outcomes Study program coordinator, Melinda Kelly, will speak. Other speakers include specialists on diabetes from the School of Medicine at Indiana University as well as from the Diabetes Research and Training Center at the University of Michigan. There will also be other speakers from the community.

Director and founder of Taking Control of Your Diabetes, Steven V. Edelman, M.D. will be at the conference. He is also School of Medicine professor at the University of California in San Diego. The founder of the Disabled Business Persons Associated (helps with the education and rehabilitation of disabled people), Urban Miyares will be the luncheon speaker.

There will be important topics during this conference. Among them are: The Truths and Myths About Insulin and Type 2 Diabetes, What's Driving You Crazy About Your Caregivers and Living with Diabetes, Raising Kids with Diabetes and Home Glucose Monitoring: Knowing Your Numbers and What to Do with Them.

There will be a health fair exhibit from 2 to 4:30 p.m. You can register and get information from 888-229-6263 which is the Office of Continuing Medical Education at UCSD. You may also register online at http://www.tcoydCME.org .

Proof of Transplantation Technology Cure

There is proof that Tissera's pancreatic xenotransplantation has just reached an important target in its quest for treatment of type 1 diabetes. After successful pancreatic transplantation in the past, Tissera went on to investigate further the value of their treatment approach.

The Weizmann Institute of Science research team treated human primates with streptozotocin to make them diabetic and dependent on the administration of insulin to maintain sensible blood glucose levels. After a stabilization period, the research team transplanted a pig embryonic pancreatic tissue into these primates.

The scientists then followed these cases up. They reduced the amount of insulin they administered. By the fourth month after they transplanted the pancreatic tissue, only 10% of insulin was needed to maintain near normal blood glucose levels. And by the fifth month, the diabetic primates reached complete independence.

For this research, the scientists also addressed the issue of graft rejection. They were able to reduce the immune suppression treatment to counteract the rejection of the graft. The dose is down to the level adequate for humans with less side effects.

Even with the lower dose of immune suppression treatment, the primate achieved complete insulin independence 18 weeks after the transplantation. Now that it is 31 weeks after transplantation, the primate is well and is still completely independent from the administration of insulin.

This is an important achievement in the company's plan to reduce the immune suppression procedure which could make it possible to use on humans. There is therefore proof that this company's way to treat type 1 diabetes has therapeutic value.

Chairman and CEO of Tissera said they are so encouraged by the results of their study that they are having more studies to move forward with their goal of making this future treatment possible for people with type 1 diabetes in the very near future.

News on Continuous Glucose Monitoring

Sugar Study on Carrot Cake and Type 2 Diabetes

Hammersmith Hospital's Department of Nutrition and Dietetics in London conducted a study on sugar. We know that diabetics are frequently advised to cut back on sugar intake but researchers have questioned this saying that a reasonable amount is safe to take as part of the diabetes diet.

So this study added three slices of carrot cake to the every day diet of nine type 2 diabetics who were overweight for 24 days. They kept a record of the participants' blood glucose levels, weight, sensitivity to insulin and cholesterol levels at the start and at the end of the research.

The leader of this research, Professor Gary Frost, said that the intake of energy of the participants was balanced to their weight and they evenly distributed the sucrose consumption over a day. Here is what they found which they published.

The participants did not gain weight. Nor did their sensitivity to insulin and their blood sugar levels, and cholesterol levels change. Professor Frost further added that while their study is small and short term, their findings support other scientific researches on the same issue.

This study demonstrated that increased daily sucrose consumption with carrot cake did not show any unfavorable effect on the diabetics' blood glucose who retained a steady body weight. So the revised approach on the diabetes diet with some flexibility on increased sugar intake is here.

In fact, Kirk et al reviewed other studies in 2000 and found that adding sugar could help lower the consumption of fat. This is of course good for the general health. The findings of this research are also agreeable with the 2007 dietary guidelines of the American Diabetes Association.

ADA says that sucrose does not have a greater bad effect on blood sugar level than the same amount of starch. It should therefore be regarded the same way as the other foods that contain carbohydrates. It can be a replacement for other carbohydrate foods but of course monitored so diabetes medication can be used correctly.

News on Continuous Glucose Monitoring

The leading company for an insulin pump technology that one can wear is Insulet Corporation. Now this company has agreed to combine their wearable insulin pump with the continuous monitoring system of DexCom. What does this mean?

Combining the two will result in a handheld OmniPod System that will be wireless with Personal Diabetes Manager which can program the diabetic's delivery of insulin. It will display glucose readings continuously. The display will be glucose values that are real-time. In addition, this combo will alert the diabetics if the sugar levels are falling or rising.

Insulet Corporation's president and CEO, Duane DeSisto, said that this latest technology proves the company's dedication to improve the lives of the diabetics. Combining the DexCom's continuous monitoring system and making it into OmniPod Personal Diabetes Manager is easy to use and will prove the benefits of continuous monitoring and insulin pump therapy.

DexCom's president and CEO, Terrance H. Gregg, said his company is glad to work with Insulet Corporation in bringing about this combo that will make managing the condition better for people with diabetes. The two technologies will certainly do that.

The combination of the two technologies will not only provide the diabetics with continuous data but also they will be able to track the trends that will make them know when to adjust their treatment. Alarms will sound off to alert the diabetics when their sugar levels are not within target levels.

The efforts to continue the development of this combo will go on through 2008 and should be ready to launch in the middle of 2009. Insulet Corporation's products for diabetes management will broaden as a result of this integration.

Investigators Explained How Alcohol Causes Hypoglycemia

Karolinska Institutet, the leading medical university in Sweden had scientists who revealed how alcohol causes hypoglycemia. Alcohol can lead to inflated secretion of insulin which in turn can lead to too low sugar, otherwise known as hypoglycemia.

Now the scientists at this Swedish university are saying that alcohol consumption can do harm to the brain. How? By lowering the concentration of blood glucose to such low levels, that's how. They have published this finding in the journal called Endocrinology.

Although hypoglycemia brought about by alcohol consumption has been a clinical problem to people with diabetes, the logistics behind this has not been unearthed or explained until now. Researchers at the Hospital Diabetes Center in Stockholm assessed the effect of alcohol.

How did they do this? They administered alcohol on the pancreatic islet and monitored its influence to the blood flow, blood glucose levels and secretion of insulin. This is what they found which may very well convince the diabetics not to consume alcohol.

The main investigator, Ake Sjoholm, said they found that alcohol affects the microcirculation in the pancreas by inducing huge redeployment of the blood flow to the part that produces insulin. This results in hypoglycemia. He further said that this finding is vital for patients with diabetes and alcoholics with liver failure.

Alcohol consumption may aggravate persistent hypoglycemia in patients with type 2 diabetes who are treated with sulfonylureas because many of these types of medications have a long half-life. Professor Sjoholm also said that most alcoholics are not properly nourished so they may not be able to respond to hypoglycemia appropriately.

Is there a Link Between Diabetes and Alzheimer?

The hormone that is vigorously involved in metabolism and blood glucose is insulin. Too little insulin causes type 1 and too much of it causes type 2 diabetes. This is a condition that is called resistance to insulin. Scientists are more and more convinced that this is a master hormone that influences the other hormones.

Researchers know that diabetics have higher risk of developing Alzheimer by up to 65% than the general population without this condition. But they did not know the answer to why this is so until now. There is a new study on this very issue.

Researchers from Boston's Joslin Diabetes Center and Cologne Germany conducted a study that suggests resistance to insulin in the brain cells can influence how it works. This can lead to the biochemical changes in people with Alzheimer.

It looks like the researchers have found out that the brain also produces insulin. And so they are now saying there is another form of diabetes which the team in Brown Medical School in the United States called type 3, but they do not think it affects the blood sugar. So now insulin could be significant to the brain.

The insulin levels are affected by this type 3 and seems to be connected with Alzheimer. This is what they published in the Journal of Alzheimer's Disease. So let's make this clear. When the body is not able to produce insulin from the pancreas, type 1 and 2 diabetes occur. This type 3 diabetes which refers to lower insulin in the brain seems connected to Alzheimer.

The scientists also found out that many of those with type 2 diabetes have protein deposits in their pancreas that are the same as those in the brain tissue of people with Alzheimer. That is why researchers are going on to find the link between the two conditions.

Rhode Island's neuropathologist Dr. Suzanne de la Monte and her team think the link is in the newly discovered type 3. This opens up new ways to treat the condition and the possibility of type 3 diabetes is raised. There is also proof that diabetes that is poorly controlled affects brain functioning. More research should be conducted to arrive at stronger conclusions.

Introduction to Type 2 Diabetes Provided

Diabetes Express is introduced by Iowa Health - Des Moines. What is it? It is a free program that will help present Type 2 diabetes. The schedule of the first event of the Diabetes Express will be held on February 5, 2008. It will be from 6:30 to 8:30 p.m. The location of the presentation is 4114 Allison Ave., Des Moines which is the Westminster Presbyterian Church.

Essential information and education will be made available regarding the importance of maintaining a healthy blood glucose control. And Diabetes Express will not stop there. It will offer strategies and ideas on how to maintain the blood sugar level.

Those who will participate in this program will learn a number of things. They will learn how to describe type 2 diabetes which is great because it is not easy to know the language that goes with this condition. Learning the importance of maintaining a healthy blood glucose level will protect future health.

The basic means of treating diabetes will be explained. And this includes planning healthy meals, doing more physical activity, losing weight and medication. The participants will be helped in identifying the goal in this regard and the strategies to reach the goal.

Sounds good, doesn't it? So, why don't you register by calling 241-5074? If you can't come they will give you information on future schedule. Or find out if you have similar events in your community. This is a good example of community involvement.

If you want more information about diabetes, please visit: Blogging for Diabetes and You

Please sign up for our free ezine entitled Diabetes Positive Approach where you will read about some encouraging news, positive experiences from others who want to share them with you and perhaps a dessert recipe good for the whole family. And you can unsubscribe anytime.

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